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Serum concentration of high density lipoproteins (HDLs) in leishmaniotic dogs

Rossi, G.ORCID: 0000-0003-4879-9504, Meazzi, S., Giordano, A., Ibba, F. and Paltrinieri, S. (2013) Serum concentration of high density lipoproteins (HDLs) in leishmaniotic dogs. Veterinary Clinical Pathology, 42 (4). E39.

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The serum concentration of high density lipoproteins (HDLs) is affected by oxidative phenomena that characterize inflammation. The aims of this study were to assess the concentration of HDLs in dogs with leishmaniasis, and to investigate the correlation between HDL, C-reactive protein (CRP), globulin fractions, and activity of the antioxidant enzyme paraoxonase (PON1). The serum concentration of HDLs was also measured during treatment to assess whether it may be a good marker to monitor response to therapy. HDLs were measured in serum from 10 leishmaniotic dogs (7 classified as sick and 3 as severely sick according to the staging system of the Canine Leishmaniasis Working Group), at admission and during the follow up (3, 7, 14, 21, and 28 days after the beginning of treatment with antimonials and allopurinol). Concentrations of total cholesterol, PON1, CRP and globulin fractions were also measured. At admission, the concentration of HDLs did not differ between sick and severely sick dogs. The correlation between HDL, PON1, CRP, and globulin fractions was assessed on the whole set of data. There was a negative correlation (P < .05, r = -0.42) between total cholesterol and c-globulins, and positive correlations between HDL and PON1 (P = .002; r = 0.55), and HDLs and A/G ratio (P = .019, r = 0.44). There was a negative correlation between HDLs and CRP (r = -0.37, P =,058). HDLs increased in sequential samples collected during the follow up after 14 and 28 days (P = .033 and P = .024). These results support an influence of c-globulins on lipid metabolism as reported in people, and suggest that inflammation is associated with a decreased HDLs concentration, likely due to the oxidative phenomena that decrease PON1 activity. Moreover, these results suggest that HDLs may be useful to assess decreased oxidation/inflammation after successful treatments. In conclusion, HDLs may serve as an additional inflammation and oxidation marker, including dogs with leishmaniasis.

Item Type: Journal Article
Publisher: American Society for Veterinary Clinical Pathology
Copyright: © 2013 American Society for Veterinary Clinical Pathology
Other Information: Poster presentation given @ European Society of Veterinary Clinical Pathology (ESVCP)/ European College of Veterinary Clinical Pathology (ECVCP) 15th Annual Congress. Berlin, Germany. 6 - 9 November 2013.
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