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Homocysteine in canine serum increases in severe kidney disease but not in inflammatory bowel disease

Rossi, G.ORCID: 0000-0003-4879-9504, Breda, S., Giordano, A., Zatelli, A. and Paltrinieri, S. (2009) Homocysteine in canine serum increases in severe kidney disease but not in inflammatory bowel disease. Veterinary Clinical Pathology, 38 (Supp. 1). E22.

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Background: In humans, homocysteine (Hcy) increases in inflammatory bowel disease (IBD) and chronic kidney disease (CKD). In a preliminary study hyperhomocysteinemia (HHcy) was detected in dogs with CKD (which, however, was not staged) but not with gastrointestinal disorders different from IBD. Objective: To assess whether dogs with IBD have HHcy and whether HHcy is associated with the severity of IBD or of CKD. Methods: This study was done on 111 serum samples from 98 dogs (6 of which were repeatedly sampled during the follow-up). Based on clinical chemistry, haematology, urinalysis, and histopathology of intestinal biopsies, dogs were classified as controls (n = 16), IBD (n = 18) or CKD (n = 64). The latter were subgrouped based on serum creatinine concentration, urine protein/creatinine ratio and blood pressure, as suggested by the International Renal Interest Society (IRIS). Results: Hcy values were not significantly different between controls (mean_SD = 6.2_2.7; median = 6.3 mmol/L) and dogs with IBD (6.5_3.6; 6.1, regardless of the type of lesions) or CKD (9.7_10.4; 6.7). Among dogs with CKD, Hcy was significantly higher (Po0.05) in dogs with stage IV CKD (12.9_12.8; 9.5), proteinuria (11.3_12.4; 7.0) or hypertension (16.6_15.2; 13.1). During follow-up, Hcy decreased in dogs with improvement of creatinine or blood pressure. Conclusions: In spite of histological changes usually associated with malabsorption, canine IBD is not associated with HHcy. By contrast, HHcy is present in dogs with severe CKD or with CKD associated with proteinuria or hypertension. The potential role of Hcy as a prognostic factor in patients with CKD merits further investigation.

Item Type: Journal Article
Publisher: American Society for Veterinary Clinical Pathology
Copyright: © 2009 American Society for Veterinary Clinical Pathology
Other Information: Oral platform presentation given @ European Society of Veterinary Clinical Pathology (ESVCP) and European College of Veterinary Clinical Pathology (ECVCP) 11th Annual College, Thessaloniki, Greece, 7 - 9 October 2009
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