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Cross-reactivity between vancomycin, teicoplanin and telavancin in HLA-A*32:01 positive vancomycin DRESS patients sharing an HLA-Class II haplotype

Nakkam, N., Gibson, A., Mouhtouris, E., Konvinse, K., Holmes, N., Chua, K.Y., Deshpande, P., Li, D., Ostrov, D.A., Trubiano, J. and Phillips, E.J. (2020) Cross-reactivity between vancomycin, teicoplanin and telavancin in HLA-A*32:01 positive vancomycin DRESS patients sharing an HLA-Class II haplotype. Journal of Allergy and Clinical Immunology . In Press.

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Embargoed until April 2021.

Link to Published Version: https://doi.org/10.1016/j.jaci.2020.04.056
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Abstract

All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to dalbavancin however two showed cross-reactivity to teicoplanin and telavancin. Adjunctive diagnostic testing should be considered to detect potential cross-reactivity amongst glycopeptides.

Item Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology
Copyright: © 2020
Other Information: Letter to the Editor
URI: http://researchrepository.murdoch.edu.au/id/eprint/56015
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