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Alzheimer's disease and other neurodegenerative diseases

Fuller, S.J., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Goozee, K.G., Sankaranarayanan, A. and Martins, R.N. (2019) Alzheimer's disease and other neurodegenerative diseases. In: Martins, R.N., Brennan, C.S., Fernando, W.M.A.D.B., Brennan, M.A. and Fuller, S.J., (eds.) Neurodegeneration and Alzheimer's Disease: The Role of Diabetes, Genetics, Hormones, and Lifestyle. John Wiley and Sons Ltd, pp. 9-42.

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Neurodegenerative diseases are a heterogeneous group of disorders or conditions characterised by the progressive degeneration of the structure and function of the central nervous system or the peripheral nervous system. Some are considered to be caused by protein misfolding, some involve disruptions to intracellular processes such as mitochondrial function or protein degradation pathways, and some are genetic in origin. Whatever the original cause of the disease, the greatest risk factor for most of these diseases is increasing age. This book is mostly focused on Alzheimer's disease (AD), yet in this chapter we describe Alzheimer's as well as other major neurodegenerative conditions to demonstrate both similarities and differences.

Item Type: Book Chapter
Publisher: John Wiley and Sons Ltd
Copyright: © 2019 John Wiley & Sons Ltd
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