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A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: Results from the Western Australia memory study

Johnson, L.A., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Hall, J.R., Taddei, K., Edwards, M., O'Bryant, S.E. and Martins, R.N. (2014) A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: Results from the Western Australia memory study. International Journal of Geriatric Psychiatry, 30 (8). pp. 881-886.

Link to Published Version: https://doi.org/10.1002/gps.4231
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Abstract

Objective
The objective was to evaluate in a cognitively normal population the utility of an endophenotype of the depression–cognition link previously shown to be related to cognitive functioning in mild cognitive impairment and Alzheimer's disease.

Methods
The data of 460 cognitively normal adults aged 32–92 years (M = 63.5, standard deviation = 9.24) from the Western Australian Memory Study with the Cross‐national comparisons of the Cambridge Cognitive Examination‐revised (CAMCOG‐R) scores and 30‐item Geriatric Depression Scale (GDS) scores were analyzed to determine the relationship between the five‐item depressive endophenotype (DepE) scale drawn from the GDS and level of performance on a measure of cognitive functioning.

Results
For the entire sample, there was a nonsignificant trend toward a negative relationship between DepE and CAMCOG‐R scores. When analyzed for those 65 years and older, there was a significant negative relationship between the two measures (p = 0.001) with DepE scores significantly increasing the risk for performing more poorly on the CAMCOG‐R (odds ratio = 1.53). Analysis of data for those 70 years and older showed that DepE was the only predictor significantly related to poorer CAMCOG‐R performance (p = 0.001). For the 70 years and older group, DepE scores significantly increased the risk of poorer CAMCOG‐R scores (odds ratio = 2.23). Analysis of the entire sample on the basis of ApoEε4 carrier status revealed that DepE scores were significantly negatively related only to ApoEε4 noncarrier regardless of age.

Conclusions
Elevated DepE scores are associated with poor neuropsychological performance among cognitively normal older adults. Use of the DepE may allow for the identification of a subset of older adults where depression is a primary factor in cognitive decline and who may benefit from antidepressant therapies.

Item Type: Journal Article
Publisher: John Wiley & Sons Ltd
Copyright: © 2014 John Wiley & Sons, Ltd.
URI: http://researchrepository.murdoch.edu.au/id/eprint/55892
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