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Hormones and Perinatal Development

Cake, M.H.ORCID: 0000-0002-5899-7291 and Yeoh, G.C.T. (2020) Hormones and Perinatal Development. In: Litwack, G., (ed.) Hormonal Signaling in Biology and Medicine. Academic Press, pp. 1-11.

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The stimulatory or inhibitory effects of numerous hormones are required for many perinatal developmental events that are essential for postnatal survival. These developmental processes include the acquisition of gluconeogenesis, amino acid catabolism, and urea biosynthetic capacity in the neonatal liver; perinatal lung maturation; and alterations to digestive enzyme capabilities upon weaning. Much of our understanding of the mechanisms underlying regulation of the relevant biochemical pathways stems from the cloning of critical genes. Transcription factor motifs and enhancer sequences have been identified in their promoter regions, which are involved in regulating their expression and their perinatal appearance. Although enhanced expression of these genes, which leads to improved metabolic capacity and versatility of the tissues, is primarily the result of de novo transcription, there is compelling evidence that posttranscriptional mechanisms can also contribute.

Item Type: Book Chapter
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: Academic Press
Copyright: © 2020 Elsevier Inc.
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