Catalog Home Page

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

Lindestam Arlehamn, C.S., Dhanwani, R., Pham, J., Kuan, R., Frazier, A., Rezende Dutra, J., Phillips, E., Mallal, S., Roederer, M., Marder, K.S., Amara, A.W., Standaert, D.G., Goldman, J.G., Litvan, I., Peters, B., Sulzer, D. and Sette, A. (2020) α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease. Nature Communications, 11 (1). pp. 1-11.

[img]
Preview
PDF - Published Version
Download (1MB) | Preview
Free to read: https://doi.org/10.1038/s41467-020-15626-w
*No subscription required

Abstract

A diagnosis of motor Parkinson’s disease (PD) is preceded by a prolonged premotor phase with accumulating neuronal damage. Here we examined the temporal relation between α-synuclein (α-syn) T cell reactivity and PD. A longitudinal case study revealed that elevated α-syn-specific T cell responses were detected prior to the diagnosis of motor PD, and declined after. The relationship between T cell reactivity and early PD in two independent cohorts showed that α-syn-specific T cell responses were highest shortly after diagnosis of motor PD and then decreased. Additional analysis revealed significant association of α-syn-specific T cell responses with age and lower levodopa equivalent dose. These results confirm the presence of α-syn-reactive T cells in PD and show that they are most abundant immediately after diagnosis of motor PD. These cells may be present years before the diagnosis of motor PD, suggesting avenues of investigation into PD pathogenesis and potential early diagnosis.

Item Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Springer Nature
Copyright: © 2020 The Author(s)
URI: http://researchrepository.murdoch.edu.au/id/eprint/55781
Item Control Page Item Control Page

Downloads

Downloads per month over past year