Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimer’s disease: Results of the DIAN Study

Laske, C., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Jasielec, M.S., Müller, S., Koehler, N.K., Gräber, S., Förster, S., Drzezga, A., Mueller-Sarnowski, F., Danek, A., Jucker, M., Bateman, R.J., Buckles, V., Saykin, A.J., Martins, R.N. and Morris, J.C. (2015) Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimer’s disease: Results of the DIAN Study. BioMed Research International, 2015 . Article ID 828120.

[img]
Preview
PDF - Published Version
Download (1MB) | Preview
Free to read: https://doi.org/10.1155/2015/828120
*No subscription required

Abstract

Objective. We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer’s disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). Methods. The baseline sample of 183 mutation carriers (MCs) and 117 noncarriers (NCs) was divided according to Clinical Dementia Rating (CDR) scale into preclinical (CDR 0; MCs: n = 107; NCs: n = 109), early symptomatic (CDR 0.5; MCs: n = 48; NCs: n = 8), and dementia stage (CDR ≥ 1; MCs: n = 28; NCs: n = 0). These groups were subdivided by the presence or absence of SMCs. Results. At CDR 0, SMCs were present in 12.1% of MCs and 9.2% of NCs (P = 0.6). At CDR 0.5, SMCs were present in 66.7% of MCs and 62.5% of NCs (P = 1.0). At CDR ≥ 1, SMCs were present in 96.4% of MCs. SMCs in MCs were significantly associated with CDR, logical memory scores, Geriatric Depression Scale, education, and estimated years to onset.

Conclusions: The present study shows that SMCs assessed by a single-item scale have no diagnostic value to identify preclinical ADAD in asymptomatic individuals. These results demonstrate the need of further improvement of SMC measures that should be examined in large clinical trials.

Item Type: Journal Article
Publisher: Hindawi Publishing Corporation
Copyright: © 2015 Christoph Laske et al.
URI: http://researchrepository.murdoch.edu.au/id/eprint/55770
Item Control Page Item Control Page

Downloads

Downloads per month over past year