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The glycocalyx: The gatekeeper to the endothelium

Smart, L.ORCID: 0000-0003-4776-2849 (2016) The glycocalyx: The gatekeeper to the endothelium. In: Annual Scientific Meeting. Australian and New Zealand College of Veterinary Scientists (ANZCVS) 2016, July 2016, Gold Coast, QLD, Australia



The endothelial glycocalyx (EG) is a carbohydrate-rich scaffold of proteoglycans and glycosaminoglycans on the luminal surface of endothelial cells. The main proteoglycans are the syndecans (Figure 1). These structures are transmembrane and play a role in transmitting shear stress signals to the cytoskeleton of the endothelial cell and also changing their binding capacity according to intracellular signalling pathway activation. They also provide an anchor for glycocoaminoglycans such as heparan sulfate. Another important glycosaminoglycan is hyaluronan, which weaves its way through the glycocalyx and is anchored by cell surface receptors such as CD44.

Item Type: Conference Paper
Murdoch Affiliation(s): School of Veterinary and Life Sciences
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