Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

Müller, S., Preische, O., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Gräber, S., Jucker, M., Ringman, J.M., Martins, R.N., McDade, E., Schofield, P.R., Ghetti, B., Rossor, M., Fox, N.N., Graff-Radford, N.R., Levin, J., Danek, A., Vöglein, J., Salloway, S., Xiong, C., Benzinger, T., Buckles, V., Masters, C.L., Sperling, R., Bateman, R.J., Morris, J.C. and Laske, C. (2018) Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia, 14 (11). pp. 1427-1437.

Link to Published Version: https://doi.org/10.1016/j.jalz.2018.06.3059
*Subscription may be required

Abstract

Introduction

Little is known about effects of physical activity (PA) in genetically driven early‐onset autosomal dominant Alzheimer's disease (AD).

Methods

A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross‐sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations.

Results

Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD‐like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers.

Discussion

These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.

Item Type: Journal Article
Publisher: Elsevier Inc.
Copyright: © 2018 The Alzheimer's Association
URI: http://researchrepository.murdoch.edu.au/id/eprint/55562
Item Control Page Item Control Page