Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults

Porter, T., Burnham, S.C., Milicic, L., Savage, G., Maruff, P., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Peretti, M., Lim, Y.Y., Weinborn, M., Ames, D., Masters, C.L., Martins, R.N., Rainey-Smith, S., Rowe, C.C., Salvado, O., Groth, D., Verdile, G., Villemagne, V.L. and Laws, S.M. (2019) COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6 . pp. 147-152.

[img]
Preview
PDF - Published Version
Download (205kB) | Preview
Free to read: https://doi.org/10.1016/j.ibror.2019.05.001
*No subscription required

Abstract

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer’s disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.

Item Type: Journal Article
Publisher: Elsevier Ltd on behalf of International Brain Research Organization
Copyright: © 2019 The Authors
URI: http://researchrepository.murdoch.edu.au/id/eprint/55556
Item Control Page Item Control Page

Downloads

Downloads per month over past year