Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Rates of age‐ and amyloid β‐associated cortical atrophy in older adults with superior memory performance

Dang, C., Yassi, N., Harrington, K.D., Xia, Y., Lim, Y.Y., Ames, D., Laws, S.M., Hickey, M., Rainey‐Smith, S., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Doecke, J.D., Fripp, J., Salvado, O., Snyder, P.J., Weinborn, M., Villemagne, V.L., Rowe, C.C., Masters, C.L., Maruff, P., Chambers, B., Chiu, E., Clarnette, R., Darby, D., Davison, M., Drago, J., Drysdale, P., Gilbert, J., Lim, K., Lautenschlager, N., LoGiudice, D., McCardle, P., McFarlane, S., Mander, A., Merory, J., O'Connor, D., Scholes, R., Samuel, M., Trivedi, D. and Woodward, M. (2019) Rates of age‐ and amyloid β‐associated cortical atrophy in older adults with superior memory performance. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11 (1). pp. 566-575.

[img]
Preview
PDF - Published Version
Download (690kB) | Preview
Free to read: https://doi.org/10.1016/j.dadm.2019.05.005
*No subscription required

Abstract

Introduction

Superior cognitive performance in older adults may reflect underlying resistance to age‐associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ‐associated neurodegeneration.

Methods

Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status.

Results

Of the case‐matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age‐ and Aβ‐associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy.

Discussion

Maintenance of superior memory in late life does not reflect resistance to age‐ or Aβ‐associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.

Item Type: Journal Article
Publisher: Elsevier Inc. on behalf of the Alzheimer’s Association
Copyright: © 2019 The Authors
URI: http://researchrepository.murdoch.edu.au/id/eprint/55551
Item Control Page Item Control Page

Downloads

Downloads per month over past year