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Aging in rodents

González-Navarro, H., Dogan, S., Tuna, B.G., Potter, P.K., Kõks, G. and Kõks, S. (2019) Aging in rodents. In: Rattan, S.I.S., (ed.) Reference Module in Biomedical Sciences. Academic Press, pp. 73-87.

Link to Published Version: https://doi.org/10.1016/B978-0-12-801238-3.11433-3
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Abstract

This article gives an overview about the aging in rodents and how rodents can be used for aging modelling. The article starts with more general consideration about the modelling and some basic background. It is followed by the review of the most common progeroid syndromes along with the molecular mechanisms of aging. Then the effect of caloric restriction is described in deeper details. And finally, the role of transposable elements and the role of their activation during aging is described. Therefore, present article covers broadly the modelling of aging in the rodents with some more detailed overviews for the mechanisms explaining the potential interventions to modify the aging and aging related problems.

Item Type: Book Chapter
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics (CMMIT)
Publisher: Academic Press
Copyright: © 2020 Elsevier Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/55027
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