Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

The role of allergy in the development of asthma

Holt, P.G., Macaubas, C., Stumbles, P.A. and Sly, P.D. (1999) The role of allergy in the development of asthma. Nature, 402 (6760S). B12-B17.

Link to Published Version:
*Subscription may be required


Recent studies have shown that initial sensitization to airborne environmental allergens occurs typically in early childhood, but subsequent progression to persistent atopic asthma, which may not manifest for several years, is restricted to only a subset of atopics. The key to establishing the link between atopy and asthma lies in the development of persistent inflammation in the airway wall, resulting in structural and functional changes in local tissues which are responsible for the symptoms of the disease. This review summarizes recent findings on the nature of the cellular and molecular mechanisms underlying this process, and addresses the issue of why the intensity and duration of these tissue-damaging responses in the airway wall apparently exceeds the critical threshold required for development of persistent asthma in only a minority of allergy sufferers.

Item Type: Journal Article
Publisher: Nature Publishing Group
Copyright: 1999 Macmillan Magazines Ltd
Item Control Page Item Control Page