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Hepatic intranuclear glycogen inclusions in western barred bandicoots (Perameles bougainville)

Bennett, M.D., Woolford, L., Nicholls, P.K.ORCID: 0000-0001-7071-3055, Warren, K.S.ORCID: 0000-0002-9328-2013 and O'Hara, A.J. (2008) Hepatic intranuclear glycogen inclusions in western barred bandicoots (Perameles bougainville). Journal of Veterinary Diagnostic Investigation, 20 (3). pp. 376-379.

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The western barred bandicoot, Perameles bougainville, is an endangered Australian marsupial species. Routine histology of liver samples collected at necropsy from 19 of 20 (95%) western barred bandicoots revealed the sporadic to common occurrence of abnormal hepatocyte nuclei characterized by margination of chromatin and concomitant central pallor. Some abnormal hepatocyte nuclei were mildly to markedly enlarged and irregularly shaped. Periodic acid-Schiff reagent stained 131 of 142 (92%) of these abnormal hepatocyte nuclei. Positive staining was completely eliminated by diastase pretreatment. Transmission electron microscopy revealed that abnormal hepatocyte nuclei with marginated chromatin did not contain viral particles. Rather, glycogen beta-particles and alpha-rosettes were identified within some abnormal hepatocyte nuclei. Glycogen intranuclear inclusions were an incidental finding in western barred bandicoot hepatocytes.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Biomedical Sciences
Publisher: American Association of Veterinary Laboratory Diagnosticians
Copyright: Copyright © 2008 by the American Association of Veterinary Laboratory Diagnosticians
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