Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Three-dimensional hemodynamic design optimization of stents for cerebral aneurysms

Lee, C-JORCID: 0000-0002-9360-0923, Srinivas, K. and Qian, Y. (2014) Three-dimensional hemodynamic design optimization of stents for cerebral aneurysms. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228 (3). pp. 213-224.

Link to Published Version: https://doi.org/10.1177/0954411914523405
*Subscription may be required

Abstract

Flow-diverting stents occlude aneurysms by diverting the blood flow from entering the aneurysm sac. Their effectiveness is determined by the thrombus formation rate, which depends greatly on stent design. The aim of this study was to provide a general framework for efficient stent design using design optimization methods, with a focus on stent hemodynamics as the starting point. Kriging method was used for completing design optimization. Three different cases of idealized stents were considered, and 40–60 samples from each case were evaluated using computational fluid dynamics. Using maximum velocity and vorticity reduction as objective functions, the optimized designs were identified from the samples. A number of optimized stent designs have been found from optimization, which revealed that a combination of high pore density and thin struts is desired. Additionally, distributing struts near the proximal end of aneurysm neck was found to be effective. The success of the methods and framework devised in this study offers a future possibility of incorporating other disciplines to carry out multidisciplinary design optimization.

Item Type: Journal Article
Publisher: SAGE Publications
URI: http://researchrepository.murdoch.edu.au/id/eprint/53247
Item Control Page Item Control Page