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Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze

Volke, V., Kõks, S., Vasar, E., Bourin, M., Bradwejn, J. and Männistö, P.T. (1995) Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze. Neuroreport, 6 (10). pp. 1413-1416.

Link to Published Version: https://doi.org/10.1097/00001756-199507100-00013
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Abstract

The action of inhibition of nitric oxide (NO) synthase by NG-nitro-L-arginine methyl ester (L-NAME) (1-20 mg kg-1) on the exploratory behaviour of rats in the elevated plus-maze was studied. L-NAME induced an anxiolytic-like effect in the plus-maze test, showing a reverse U-shape action behaviour, with a maximal effect at 10 mg kg-1. This effect was not related to a non-specific increase in motor activity, since in the open field test L-NAME did not affect locomotor activity of rats. Pretreatment of rats with L-NAME (1-10 mg kg-1) also tended to attenuate the anti-exploratory action of CCK agonist caerulein (5 micrograms kg-1), but this action was not significant. In conclusion, it appears that NO may be involved in the process that can lead to anxiety in the rat.

Item Type: Journal Article
Publisher: Lippincott Williams & Wilkins
URI: http://researchrepository.murdoch.edu.au/id/eprint/53013
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