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Nitric oxide mediates caeruleininduced suppression of locomotor activity

Volke, V., Soosaar, A., Kõks, S., Bourin, M., Männistö, P.T. and Vasar, E. (1996) Nitric oxide mediates caeruleininduced suppression of locomotor activity. Neuropeptides, 30 (4). pp. 323-326.

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Caerulein, a non-selective agonist of cholecystokinin (CCK) receptors, is shown to suppress locomotor activity in rodents via stimulation of CCKA receptors. In the present study we examined the possible involvement of nitric oxide (NO) in caerulein-induced hypolocomotion in rats. Caerulein (10 μg/kg) markedly decreased the horizontal and vertical components of locomotor activity in rats measured in dark motility boxes. Pretreatment with a nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME), at 5 mg/kg i.p., abolished the inhibiting action of caerulein on the horizontal activity, but did not affect the reduced frequency of rearing. The other doses of l-NAME (1, 10 and 20 mg/kg) were ineffective against caerulein. As L-NAME at this dose range does not stimulate locomotor activity, it is likely that NO is involved in the motor suppressant effect of systemically administered caerulein.

Item Type: Journal Article
Publisher: Elsevier
Copyright: © 1996 Elsevier Ltd.
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