Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

An output-based knowledge transfer approach and its application in bladder cancer prediction

Wang, G.ORCID: 0000-0002-5258-0532, Zhang, G., Choi, K-S, Lam, K-M and Lu, J. (2017) An output-based knowledge transfer approach and its application in bladder cancer prediction. In: 2017 International Joint Conference on Neural Networks (IJCNN), 14 - 19 May 2017, Anchorage, AK, USA pp. 356-363.

Link to Published Version:
*Subscription may be required


Many medical applications face a situation that the on-hand data cannot fully fit an existing predictive model or on-line tool, since these models or tools only use the most common predictors and the other valuable features collected in the current scenario are not considered altogether. On the other hand, the training data in the current scenario is not sufficient to learn a predictive model effectively yet. In order to overcome these problems and construct an efficient classifier, for these real situations in medical fields, in this work we present an approach based on the least squares support vector machine (LS-SVM), which utilizes a transfer learning framework to make maximum use of the data and guarantee its enhanced generalization capability. The proposed approach is capable of effectively learning a target domain with limited samples by relying on the probabilistic outputs from the other previously learned model using a heterogeneous method in the source domain. Moreover, it autonomously and quickly decides how much output knowledge to transfer from source domain to the target one using a fast leave-one-out cross validation strategy. This approach is applied on a real-world clinical dataset to predict 5-year mortality of bladder cancer patients after radical cystectomy, and the experimental results indicate that the proposed method can achieve better performances compared to traditional machine learning methods, consistently showing the potential of the proposed method under the circumstances with insufficient data.

Item Type: Conference Paper
Publisher: IEEE
Copyright: © 2017 IEEE
Item Control Page Item Control Page