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Evaluation of a modified high-definition electrode montage for transcranial alternating current stimulation (tACS) of pre-central areas

Heise, K-F., Kortzorg, N., Saturnino, G.B., Fujiyama, H.ORCID: 0000-0002-7546-6636, Cuypers, K., Thielscher, A. and Swinnen, S.P. (2016) Evaluation of a modified high-definition electrode montage for transcranial alternating current stimulation (tACS) of pre-central areas. Brain Stimulation, 9 (5). pp. 700-704.

Link to Published Version: https://doi.org/10.1016/j.brs.2016.04.009
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Abstract

Objective

To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation.

Methods

In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation).

Results

Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage.

Conclusions

In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.

Item Type: Journal Article
Publisher: Elsevier
Copyright: © 2016 Elsevier Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/52122
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