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Temperature dependence of the sodium pump is altered in the cerebral cortex of CCK2 receptor-deficient mice

Salum, T., Kõks, S., Kairane, C., Mahlapuu, R., Zilmer, M. and Vasar, E. (2010) Temperature dependence of the sodium pump is altered in the cerebral cortex of CCK2 receptor-deficient mice. Neurochemical Research, 35 (5). pp. 688-692.

Link to Published Version: https://doi.org/10.1007/s11064-009-0119-1
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Abstract

Previously we have shown that the temperature dependence of the sodium pump (Na+,K+-ATPase) is altered under different neuropathological conditions. In this study we compared temperature dependence of the Na+,K+-ATPase in the fronto-parietal cortex of CCK2 receptor-deficient (homo- and heterozygous) and normal (wild-type) mice. The Arrhenius plot for Na+,K+-ATPase from wild-type brain is non-linear with a breakpoint at 20.3 ± 0.4°C. In case of the brain cell membrane of CCK2 receptor-deficient mice (homo- and heterozygous) the breakpoint on Arrhenius plot was detected at 26.0 ± 1.1°C and 25.4 ± 0.4°C, respectively. The shift of the breakpoint on the Arrhenius plot established in CCK2 receptor-deficiency as well as in case of some other pathological conditions confirms that such kind of alteration in the Na+,K+-ATPase temperature dependence is likely related to the homeostatic adjustment of altered function of the sodium pump.

Item Type: Journal Article
Publisher: Springer US
Copyright: © 2010 Springer Science+Business Media, LLC
URI: http://researchrepository.murdoch.edu.au/id/eprint/51930
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