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Mouse models of ageing and their relevance to disease

Kõks, S., Dogan, S., Tuna, B.G., González-Navarro, H., Potter, P. and Vandenbroucke, R.E. (2016) Mouse models of ageing and their relevance to disease. Mechanisms of Ageing and Development, 160 . pp. 41-53.

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Ageing is a process that gradually increases the organism’s vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.

Item Type: Journal Article
Publisher: Elsevier
Copyright: © 2016 The Authors.
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