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Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese

Asser, A., Kõks, S., Snellman, A., Haaparanta-Solin, M., Arponen, E., Grönroos, T., Nairismägi, J., Bergquist, J., Soomets, U., Piip, P., Eltermaa, M., Sauk, M., Lindmäe, H., Rinne, J.O. and Taba, P. (2016) Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese. Brain Research, 1652 . pp. 97-102.

Link to Published Version: https://doi.org/10.1016/j.brainres.2016.09.034
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Abstract

Intravenous use of a psychostimulant drug containing methcathinone (ephedrone) and manganese causes an irreversible extrapyramidal syndrome in drug abusers. We aimed to reproduce the syndrome in mice to evaluate dopaminergic damage.

C57/B6 mice were intraperitoneally injected once a day with the study drug or saline for a period of 27 weeks. Motor activity was recorded in an automated motility-box. After 13 and 27 weeks of treatment, ex vivo digital autoradiography was performed using [11C]dihydrotetrabenazine ([11C]DTBZ).

After 27 weeks of treatment [11C]DTBZ autoradiography demonstrated a significant increase in the striatum-to-cerebellum binding ratio compared with saline treated controls. At the same time point, there was no evident change in motor activity.

Increased [11C]DTBZ binding may indicate vesicular monoamine transporter type 2 (VMAT2) function is altered. The lack of extrapyramidal symptoms in animals could be attributed to low dosing regimen or high metabolic rate.

Item Type: Journal Article
Publisher: Elsevier BV
Copyright: © 2016 Elsevier B.V.
URI: http://researchrepository.murdoch.edu.au/id/eprint/51452
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