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Effect of IGF-1 gene polymorphism on bone mineral density in osteoporotic postmenopausal Sudanese women

Mohamed, H., Ismail, A. and Braima, K. (2019) Effect of IGF-1 gene polymorphism on bone mineral density in osteoporotic postmenopausal Sudanese women. Osteoporosis International, 30 (S2). pp. 253-773.

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Objective: BMD is the hallmark of OP and exhibits high heritability; efforts to understand OP genetic determinants have therefore been increased. In this study a polymorphism of IGF-I gene was examined in Sudanese postmenopausal women to analyse the genetic background for osteoporosis.

Method: A cross-sectional study conducted during the periodof 2014-2015. We studied 836 women refereed to our hospital. Based on the DXA results and inclusion criteria 121 postmeno-pause women (45-80 years old) were selected. Classified intothree groups, osteoporotic, T-score (≥-2.5), osteopenia, T-score(-1 to -2.5) and normal, T-score (≤-1) as the control group. A most common single nucleotide polymorphisms (SNP) in (IGF-1) gene (rs35767) were measured using RT-PCR TaqMan. Serum concentration of IGF-1 was measured by ADVIA(Siemens Healthcare Diagnostics Inc., Deerfield, IL, USA).

Results: The IGF-I SNP (rs11568820) CC genotype was found to be associated with osteoporosis and BMD at the total hip (not lumbar spine (L1–L4) under recessive and additive genetic model (AOR (95%CI)=2.0(1.0-8); p=0.0) and (OR(95%CI)=1.5 (0.1-7); p=0.02) respectively. Serum level of IGF-I was strongly associated with decreased BMD with level significantly decreasing (P<0.01).

Conclusions: We found significant associations between CC genotype of IGF-1 rs35767, BMD and osteoporosis risk, suggesting that IGF-1 rs35767 can be used as a predictive factor for determining the risk of osteoporosis. Serum IGF-1 can be used as predictor marker for determine early decreased BMD. Further study with large sample size are needed to confirm the results of our study.

Item Type: Journal Article
Publisher: Springer London
Copyright: © 2019 International Osteoporosis Foundation and National Osteoporosis Foundation
Other Information: Conference title: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019)
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