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Bond dissociation energies and radical stabilization energies associated with substituted methyl radicals

Henry, D.J.ORCID: 0000-0002-9629-4423, Parkinson, C.J., Mayer, P.M. and Radom, L. (2001) Bond dissociation energies and radical stabilization energies associated with substituted methyl radicals. The Journal of Physical Chemistry A, 105 (27). pp. 6750-6756.

Link to Published Version: http://dx.doi.org/10.1021/jp010442c
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Abstract

Bond dissociation energies (BDEs) and radical stabilization energies (RSEs) associated with a series of 22 monosubstituted methyl radicals (•CH2X) have been determined at a variety of levels including, CBS-RAD, G3(MP2)-RAD, RMP2, UB3-LYP and RB3-LYP. In addition, W1′ values were obtained for a subset of 13 of the radicals. The W1′ BDEs and RSEs are generally close to experimental values and lead to the suggestion that a small number of the experimental estimates warrant reexamination. Of the other methods, CBS-RAD and G3(MP2)-RAD produce good BDEs. A cancellation of errors leads to reasonable RSEs being produced from all the methods examined. CBS-RAD, W1′ and G3(MP2)-RAD perform best, while UB3-LYP performs worst. The substituents (X) examined include lone-pair-donors (X = NH2, OH, OCH3, F, PH2, SH, Cl, Br and OCOCH3), π-acceptors (X = BH2, CH=CH2, C≡CH, C6H5, CHO, COOH, COOCH3, CN and NO2) and hyperconjugating groups (CH3, CH2CH3, CF3 and CF2CF3). All substituents other than CF3 and CF2CF3 result in radical stabilization, with the vinyl (CH=CH2), ethynyl (C≡CH) and phenyl (C6H5) groups predicted to give the largest stabilizations of the π-acceptor substituents examined and the NH2 group calculated to provide the greatest stabilization of the lone-pair-donor groups. The substituents investigated in this work stabilize methyl radical centers in three general ways that delocalize the odd electron: π-acceptor groups (unsaturated substituents) delocalize the unpaired electron into the π-system of the substituent, lone-pair-donor groups (heteroatomic substituents) bring about stabilization through a three-electron interaction between a lone pair on the substituent and the unpaired electron at the radical center, while alkyl groups stabilize radicals via a hyperconjugative mechanism. Polyfluoroalkyl substituents are predicted to slightly destabilize a methyl radical center by inductively withdrawing electron density from the electron-deficient radical center.

Item Type: Journal Article
Publisher: American Chemical Society
Copyright: © 2001 American Chemical Society
URI: http://researchrepository.murdoch.edu.au/id/eprint/4968
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