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Molecular model of Prion transmission to humans

Jones, M.ORCID: 0000-0001-5002-0227, Wight, D., Barron, R., Jeffrey, M., Manson, J., Prowse, C., Ironside, J.W. and Head, M.W. (2009) Molecular model of Prion transmission to humans. Emerging infectious diseases, 15 (12). pp. 2013-2016.

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To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.

Item Type: Journal Article
Publisher: Centers for Disease Control and Prevention (CDC)
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