Molecular model of Prion transmission to humans
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Jones, M.
ORCID: 0000-0001-5002-0227, Wight, D., Barron, R., Jeffrey, M., Manson, J., Prowse, C., Ironside, J.W. and Head, M.W.
(2009)
Molecular model of Prion transmission to humans.
Emerging infectious diseases, 15
(12).
pp. 2013-2016.
Link to Published Version: https://doi.org/10.3201/eid1512.090194
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Abstract
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
| Item Type: | Journal Article |
|---|---|
| Publisher: | Centers for Disease Control and Prevention (CDC) |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/49453 |
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