Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Molecular model of Prion transmission to humans

Jones, M.ORCID: 0000-0001-5002-0227, Wight, D., Barron, R., Jeffrey, M., Manson, J., Prowse, C., Ironside, J.W. and Head, M.W. (2009) Molecular model of Prion transmission to humans. Emerging infectious diseases, 15 (12). pp. 2013-2016.

Link to Published Version: https://doi.org/10.3201/eid1512.090194
*Subscription may be required

Abstract

To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.

Item Type: Journal Article
Publisher: Centers for Disease Control and Prevention (CDC)
URI: http://researchrepository.murdoch.edu.au/id/eprint/49453
Item Control Page Item Control Page