Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential
Krejciova, Z., Barria, M.A., Jones, M.ORCID: 0000-0001-5002-0227, Ironside, J.W., Jeffrey, M., González, L. and Head, M.W.
(2014)
Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential.
Journal of Biological Chemistry, 289
(38).
pp. 26075-26088.
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Abstract
Background: The results of serial passage of BSE in sheep are unknown.
Results: In vitro modeling shows a sheep genotype-dependent switch in prion protein type and loss of the ability to convert human prion protein.
Conclusion: Molecular evolution of sheep BSE prions in vitro is genotype-dependent and affects zoonotic potential.
Significance: Zoonotic risk might be predicted from cell-free modeling.
Item Type: | Journal Article |
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Publisher: | American Society for Biochemistry and Molecular Biology Inc. |
Copyright: | © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/49440 |
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