Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential

Krejciova, Z., Barria, M.A., Jones, M.ORCID: 0000-0001-5002-0227, Ironside, J.W., Jeffrey, M., González, L. and Head, M.W. (2014) Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential. Journal of Biological Chemistry, 289 (38). pp. 26075-26088.

Free to read: https://doi.org/10.1074/jbc.M114.582965
*No subscription required

Abstract

Background: The results of serial passage of BSE in sheep are unknown.

Results: In vitro modeling shows a sheep genotype-dependent switch in prion protein type and loss of the ability to convert human prion protein.

Conclusion: Molecular evolution of sheep BSE prions in vitro is genotype-dependent and affects zoonotic potential.

Significance: Zoonotic risk might be predicted from cell-free modeling.

Item Type: Journal Article
Publisher: American Society for Biochemistry and Molecular Biology Inc.
Copyright: © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/49440
Item Control Page Item Control Page