Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential

Krejciova, Z., Barria, M.A., Jones, M.ORCID: 0000-0001-5002-0227, Ironside, J.W., Jeffrey, M., González, L. and Head, M.W. (2014) Genotype-dependent molecular evolution of sheep Bovine Spongiform Encephalopathy (BSE) prionsin vitro affects their zoonotic potential. Journal of Biological Chemistry, 289 (38). pp. 26075-26088.

Abstract

Background: The results of serial passage of BSE in sheep are unknown.

Results: In vitro modeling shows a sheep genotype-dependent switch in prion protein type and loss of the ability to convert human prion protein.

Conclusion: Molecular evolution of sheep BSE prions in vitro is genotype-dependent and affects zoonotic potential.

Significance: Zoonotic risk might be predicted from cell-free modeling.

Item Type:	Journal Article
Publisher:	American Society for Biochemistry and Molecular Biology Inc.
Copyright:	© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/49440

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