Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats

DeClue, A.E., Sharp, C.R.ORCID: 0000-0002-1797-9783, Cohen, R.L., Leverenz, E.F. and Reinero, C.R. (2010) Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats. Journal of Feline Medicine and Surgery, 12 (10). pp. 754-759.

Abstract

This study evaluated the effects of a cysteinyl-leukotriene-1 (cys-LT-1) receptor antagonist, zarfirlukast, during feline endotoxemia. Six adult, sexually intact male cats received either placebo or zarfirlukast (10 mg, PO) and endotoxin (2 μg/kg/h q 6 h) in a cross-over design. Rectal temperature, heart rate, systolic arterial blood pressure, plasma tumor necrosis factor (TNF) activity, interleukin (IL)-6 concentration and urine cys-LT to creatinine ratio were evaluated. The rectal temperature, plasma TNF activity and IL-6 concentrations were significantly higher and systolic arterial blood pressure and heart rate significantly lower after endotoxin infusion. Cats treated with zafirlukast had a significantly higher blood pressure at 4 h (P=0.002) compared to placebo. Urine cys-LT to creatinine ratio was significantly greater in the cats treated with zafirlukast compared to placebo (P=0.02). Zafirlukast administration ameliorated the acute hypotensive response to endotoxin in cats, but failed to significantly alter rectal temperature, heart rate or production of TNF and IL-6.

Item Type:	Journal Article
Publisher:	Elsevier Ltd.
Copyright:	© 2010 ISFM and AAFP
URI:	http://researchrepository.murdoch.edu.au/id/eprint/48794

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