Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons)

Death, C.E., Taggart, D.A., Williams, D.B., Milne, R., Schultz, D.J., Holyoake, C.S. and Warren, K.S.ORCID: 0000-0002-9328-2013 (2011) Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons). Journal of Wildlife Diseases, 47 (3). pp. 643-649.

PDF - Published Version
Download (308kB)
Link to Published Version:
*Subscription may be required


Sarcoptic mange, caused by Sarcoptes scabiei var. wombati, could be a significant threat to populations of southern hairy-nosed wombats (Lasiorhinus latifrons; SHNW) in Australia. Treatment is currently based on the off-label use of various parasiticidal drugs, with limited clinical efficacy trials. Our primary aim was to determine the pharmacokinetic parameters of a macrocyclic lactone, moxidectin, to assist in the development of effective treatment protocols. Pharmacokinetic parameters were determined in four female SHNW following a single subcutaneous injection of 0.2 mg/kg moxidectin. Blood samples were collected for 38 days following injection (August-September 2008), for analysis using liquid chromatography and tandem mass spectrometry. The mean peak plasma concentration occurred at 13.6 hr, with a mean peak plasma level of 98.6 ng/ml. The mean elimination half-life was 5.03 days, resulting in a mean area under the curve of 377 The peak plasma moxidectin concentration was higher than that seen in livestock species but the plasma elimination half-life was shorter. This study suggests that a single injection of 0.2 mg/kg moxidectin may not be sufficient to clear a mange infection in this species.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Biomedical Sciences
Publisher: Wildlife Disease Association
Copyright: © Wildlife Disease Association 2011
Item Control Page Item Control Page


Downloads per month over past year