A review of synthetic fentanyl metabolism and the metabolism of select synthetic fentanyl analogues

Lee, Gerard (2019) A review of synthetic fentanyl metabolism and the metabolism of select synthetic fentanyl analogues. Masters by Research thesis, Murdoch University.

Abstract

Fentanyl is a fast acting, potent synthetic opioid. It is also used as a narcotic of abuse posing a life-threatening hazard to everyone that comes into contact with it. The illicit production of new fentanyl analogues creates challenges as new analytical approaches have to be developed in order to identify the new analogues and their metabolites. Further understanding of metabolites and metabolic pathways would therefore improve the ability to identify new analogues. This review compiles knowledge on in vivo and in vitro metabolism of specific fentanyl analogues to identify common metabolic pathways and fragmentation patterns of key metabolites to assist in the identification of novel fentanyl analogues.

Item Type:	Thesis (Masters by Research)
Murdoch Affiliation(s):	School of Veterinary and Life Sciences
Supervisor(s):	Speers, James and Mead, Robert
URI:	http://researchrepository.murdoch.edu.au/id/eprint/48245

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