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Analysis of haplotype sequences

Lloyd, S.S.ORCID: 0000-0002-0118-3094, Steele, E.J. and Dawkins, R.L. (2016) Analysis of haplotype sequences. In: Next Generation Sequencing - Advances, Applications and Challenges. InTech Open, pp. 346-368.

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In this era of whole-genome, next-generation sequencing, it is important to have a clear understanding of the concept of “haplotype”. We show here that most of the important regions of the genome can be described in terms of polymorphic frozen blocks (PFB). At each PFB, there are numerous, even hundreds, of alternative ancestral haplotypes. Haplotypes, not genes, can be regarded as the principal unit of inheritance. We illustrate how sequence data can be analysed to reveal and define these ancestral haplotypes.

Item Type: Book Chapter
Murdoch Affiliation(s): School of Engineering and Information Technology
Publisher: InTech Open
Copyright: © 2015 The Author(s).
United Nations SDGs: Goal 3: Good Health and Well-Being
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