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A human sensory pathway connecting the foot to ipsilateral face that partially bypasses the spinal cord

Silberstein, M., Nunn, A.K., Drummond, P.D.ORCID: 0000-0002-3711-8737, Wan, D.W.L., Alexander, J., Millard, M. and Galea, M.P. (2019) A human sensory pathway connecting the foot to ipsilateral face that partially bypasses the spinal cord. Frontiers in Neuroscience, 13 . Article 519.

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Human sensory transmission from limbs to brain crosses and ascends through the spinal cord. Yet, descriptions exist of ipsilateral sensory transmission as well as transmission after spinal cord transection. To elucidate a novel ipsilateral cutaneous pathway, we measured facial perfusion following painfully-cold water foot immersion in 10 complete spinal cord-injured patients, 10 healthy humans before and after lower thigh capsaicin C-fiber cutaneous conduction blockade, and 10 warm-immersed healthy participants. As in healthy volunteers, ipsilateral facial perfusion in spinal cord injured patients increased significantly. Capsaicin resulted in contralateral increase in perfusion, but only following cold immersion and not in 2 spinal cord-injured patients who underwent capsaicin administration. Supported by skin biopsy results from a healthy participant, we speculate that the pathway involves peripheral C-fiber cross-talk, partially bypassing the cord. This might also explain referred itch and jogger's migraine and it is possible that it may be amenable to training spinal-injured patients to recognize lower limb sensory stimuli.

Item Type: Journal Article
Murdoch Affiliation(s): School of Psychology and Exercise Science
Publisher: Frontiers Media
Copyright: © 2019 The Author(s)
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