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Cardiovascular effects of two adenosine constant rate infusions in anaesthetised dogs

Joerger, F.B., Dennler, M., Meira, C., Mosing, M., Richter, H. and Ringer, S.K. (2019) Cardiovascular effects of two adenosine constant rate infusions in anaesthetised dogs. Veterinary Anaesthesia and Analgesia, 46 (3). pp. 289-298.

Link to Published Version: https://doi.org/10.1016/j.vaa.2018.12.007
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Abstract

Objective

Adenosine induces vasodilatation. The aim of this study was to investigate cardiovascular effects of two adenosine constant rate infusion (CRI) doses in dogs.

Study design

Experimental, longitudinal repeated measure design

Animals

Ten healthy purpose-bred Beagle dogs

Methods

Each dog was sedated with butorphanol. Anaesthesia was induced with propofol intravenously (IV) and maintained with sevoflurane [inspired oxygen fraction (FIO2) = 47-55%]. Controlled mechanical ventilation was used to maintain normocapnia. Each dog received two consecutive adenosine CRIs: 140 μg kg-1 minute-1 (A140) followed by 280 μg kg-1 minute-1 (A280). Pulse rate (PR), invasive arterial pressure and stroke volume [SVMRT; by magnetic resonance phase contrast angiography (Q-Flow)] were measured at baseline, 3 minutes after starting adenosine and 3 and 10 minutes after discontinuing adenosine. Cardiac output (CO), cardiac index (CI) and approximated systemic vascular resistances (approximate SVR) were calculated. Additionally, arterial blood gases, co-oximetry, electrolytes, glucose and lactate were measured and oxygen content (CaO2) and delivery (DO2) calculated. One-way repeated measures ANOVA (p < 0.05) was used for data analysis.

Results

A140 and A280 resulted in a significant decrease in arterial blood pressure (systolic arterial pressure (SAP) (p = 0.008), mean arterial pressure (MAP) (p = 0.003) and diastolic arterial pressure (DAP) (p = 0.004)) and approximate SVR (p = 0.008) compared to baseline. No significant changes were detected for the other variables. All values returned to baseline within 3 minutes after adenosine discontinuation.

Conclusions

and clinical relevance Adenosine CRI decreases arterial pressure by vasodilatation in healthy dogs. No additional effects were observed with the higher dose. The effects in compromised dogs remain to be investigated.

Keywords: adenosine;;anaesthesia; cardiovascular; cMRI; dog

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: Elsevier Ltd.
Copyright: © 2019 Published by Elsevier Ltd on behalf of Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia
URI: http://researchrepository.murdoch.edu.au/id/eprint/43556
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