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Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials

Fletcher, N.L., Houston, Z.H., Simpson, J.D., Veedu, R.N. and Thurecht, K.J. (2018) Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials. Chemical Communications, 54 (82). pp. 11538-11541.

Link to Published Version: https://doi.org/10.1039/c8cc05831h
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Abstract

We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.

Item Type: Journal Article
Murdoch Affiliation: Centre for Comparative Genomics
Publisher: Royal Society of Chemistry
Copyright: ©The Royal Society of Chemistry 2018
URI: http://researchrepository.murdoch.edu.au/id/eprint/42414
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