Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA

Moore, E., Grifoni, A., Weiskopf, D., Schulten, V., Arlehamn, C.S.L., Angelo, M., Pham, J., Leary, S., Sidney, J., Broide, D., Frazier, A., Phillips, E., Mallal, S., Mack, S.J. and Sette, A. (2018) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA. Human Immunology, 79 (12). pp. 821-822.

Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the class I allele A∗02:01. Genotype data will be available in the Allele Frequencies Net Database (AFND 3562).

Item Type:	Journal Article
Murdoch Affiliation(s):	Institute for Immunology and Infectious Diseases
Publisher:	Elsevier BV
Copyright:	© 2018 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/42277

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