Clinical importance of steps taken per day among persons with Multiple Sclerosis

Motl, R.W., Pilutti, L.A., Learmonth, Y.C.ORCID: 0000-0002-4857-8480, Goldman, M.D. and Brown, T. (2013) Clinical importance of steps taken per day among persons with Multiple Sclerosis. PLoS ONE, 8 (9). e73247.

Abstract

Background
The number of steps taken per day (steps/day) provides a reliable and valid outcome of free-living walking behavior in persons with multiple sclerosis (MS).

Objective
This study examined the clinical meaningfulness of steps/day using the minimal clinically important difference (MCID) value across stages representing the developing impact of MS.

Methods
This study was a secondary analysis of de-identified data from 15 investigations totaling 786 persons with MS and 157 healthy controls. All participants provided demographic information and wore an accelerometer or pedometer during the waking hours of a 7-day period. Those with MS further provided real-life, health, and clinical information and completed the Multiple Sclerosis Walking Scale-12 (MSWS-12) and Patient Determined Disease Steps (PDDS) scale. MCID estimates were based on regression analyses and analysis of variance for between group differences.

Results
The mean MCID from self-report scales that capture subtle changes in ambulation (1-point change in PDSS scores and 10-point change in MSWS-12 scores) was 779 steps/day (14% of mean score for MS sample); the mean MCID for clinical/health outcomes (MS type, duration, weight status) was 1,455 steps/day (26% of mean score for MS sample); real-life anchors (unemployment, divorce, assistive device use) resulted in a mean MCID of 2,580 steps/day (45% of mean score for MS sample); and the MCID for the cumulative impact of MS (MS vs. control) was 2,747 steps/day (48% of mean score for MS sample).

Conclusion
The change in motion sensor output of ∼800 steps/day appears to represent a lower-bound estimate of clinically meaningful change in free-living walking behavior in interventions of MS.

Item Type:	Journal Article
Publisher:	Public Library of Science
Copyright:	© 2013 Motl et al.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/42015

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