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Validity of minimal clinically important difference values for the Multiple Sclerosis walking Scale-12?

Motl, R.W., Learmonth, Y.C.ORCID: 0000-0002-4857-8480, Pilutti, L.A., Dlugonski, D. and Klaren, R. (2014) Validity of minimal clinically important difference values for the Multiple Sclerosis walking Scale-12? European Neurology, 71 (3-4). pp. 196-202.

Link to Published Version: https://doi.org/10.1159/000356116
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Abstract

Background and Objective: Minimal clinically important difference (MCID) values of 4 and 6 points have been proposed for interpreting meaningful change in Multiple Sclerosis Walking Scale-12 (MSWS-12) scores. This study examined the validity of those MCID values based on capturing corresponding changes in other walking outcomes in persons with multiple sclerosis (MS). Methods: On 2 occasions separated by 6 months, 82 persons with MS completed the MSWS-12, timed 25-ft walk (T25FW), 6-min walk (6MW), and gait analysis, and then wore an accelerometer over a 7-day period. We generated change scores for the MSWS-12 and formed groups of stable, worsened, and improved perceived walking based on both 4- and 6-point changes. The groups were compared for corresponding changes in other walking measures over time using mixed-model ANOVAs. Results: The mixed-model ANOVAs did not identify statistically significant group-by-time interactions on the T25FW (p = 0.98 and p = 0.67), the 6MW (p = 0.89 and p = 0.72), gait (p = 0.54 and p = 0.21), or accelerometry (p = 0.40 and p = 0.68) for MCID values of 4- or 6-point changes in MSWS-12 scores. Conclusions: We did not confirm that MCID values of 4 and 6 points for the MSWS-12 correspond with changes in performance, gait, and free-living assessments of walking in MS.

Item Type: Journal Article
Publisher: Karger
Copyright: © 2014 S. Karger AG, Basel
URI: http://researchrepository.murdoch.edu.au/id/eprint/41978
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