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Compression socks and the effects on coagulation and fibrinolytic activation during marathon running

Zadow, E.K., Adams, M.J.ORCID: 0000-0002-7743-4515, Wu, S.S.X., Kitic, C.M., Singh, I., Kundur, A., Bost, N., Johnston, A.N.B., Crilly, J., Bulmer, A.C., Halson, S.L. and Fell, J.W. (2018) Compression socks and the effects on coagulation and fibrinolytic activation during marathon running. European Journal of Applied Physiology, 118 (10). pp. 2171-2177.

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Purpose: Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear.

Objectives: To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon.

Methods: Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40.0 ± 11.0 year)] were allocated into a compression (SOCK, n = 34) or control (CONTROL, n = 33) group. Venous blood samples were obtained 24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and D-Dimer.

Results: Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median (range) SOCK: + 9.02 (− 0.34 to 60.7) ng/mL, CONTROL: + 25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: + 1.19 (− 7.47 to 9.11) pg/mL, CONTROL: + 3.47 (− 5.01 to 38.56) pg/mL] in all runners. No significant post-exercise changes were observed for TAT and TFPI.

Conclusions: While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression may reduce exercise-associated haemostatic activation when completing prolonged exercise.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: Springer Verlag
Copyright: © 2018 Springer-Verlag GmbH Germany, part of Springer Nature
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