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A review of the collision induced dissociation fragmentation and the metabolism of synthetic cathinone derivatives

Cunningham, Nichola (2018) A review of the collision induced dissociation fragmentation and the metabolism of synthetic cathinone derivatives. Masters by Coursework thesis, Murdoch University.

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Synthetic cathinones constitute one of the most commonly abused new psychoactive substances. The rapid development of synthetic cathinones creates a challenge for forensic laboratories to develop and maintain analytical methods for identifying and quantifying synthetic cathinones and their metabolites in illicit drug and toxicological samples. The characterisation of synthetic cathinone metabolites is therefore important for both developing an understanding of their pharmacokinetics and for identifying unique metabolites that could be used for identification. In this review, the current state of knowledge regarding the metabolism of synthetic cathinones will be discussed; focussing primarily on the human in vitro and in vivo metabolism, with the objective of providing a systematic overview of the currently known metabolic profiles. In addition to this, the mass-spectral dissociation fragmentation pathways of synthetic cathinones will be reviewed in an attempt to identify common fragmentation patterns that may assist in the identification of previously unidentified synthetic cathinones.

Keywords: Synthetic cathinones; Metabolism; Cathinone Fragmentation patterns; Novel psychoactive substances; Collision induced dissociation.

Item Type: Thesis (Masters by Coursework)
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Supervisor(s): Coumbaros, John
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