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Sjögren syndrome with associated lymphocytic interstitial pneumonia successfully treated With tacrolimus and abatacept as an alternative to rituximab

Thompson, G., McLean-Tooke, A., Wrobel, J., Lavender, M. and Lucas, M. (2018) Sjögren syndrome with associated lymphocytic interstitial pneumonia successfully treated With tacrolimus and abatacept as an alternative to rituximab. Chest, 153 (3). e41-e43.

Link to Published Version: https://doi.org/10.1016/j.chest.2017.12.010
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Abstract

Interstitial lung disease (ILD) is a significant complication of Sjögren syndrome (SS) associated with increased morbidity and mortality. The mainstay of treatment remains corticosteroid administration, with or without additional immunosuppressive therapies. Preliminary studies in SS have shown benefit in glandular and serologic parameters following treatment with the CTLA4 immunoglobulin fusion protein abatacept. Topical tacrolimus has been effective for ocular symptoms in SS, but systemic therapy has not been reported. We describe the first case, to our knowledge, of the successful use of a combination of systemic tacrolimus and abatacept in severe refractory SS and related ILD.

Item Type: Journal Article
Publisher: Elsevier
Copyright: © 2017 American College of Chest Physicians.
URI: http://researchrepository.murdoch.edu.au/id/eprint/41484
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