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Association of serum Cystatin C with neuromyelitis optica spectrum disorders

Shu, Y., Zhang, L., Chang, Y., Li, R., Sun, X., Li, J., Wu, H., Yang, Y., Peng, L., Lu, Z., Kermode, A.G. and Qiu, W. (2018) Association of serum Cystatin C with neuromyelitis optica spectrum disorders. European Journal of Neurology, 25 (7). pp. 999-1002.

Link to Published Version: https://doi.org/10.1111/ene.13646
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Abstract

Background and purpose
The relationship between Cystatin C (CysC) and neuromyelitis optica spectrum disorders (NMOSD) is unknown.

Methods
Serum CysC levels were measured in 105 Chinese patients with NMOSD (53 in relapse, 52 in remission) and 109 healthy controls (HCs). The association of CysC with NMOSD and its clinical and magnetic resonance imaging parameters were evaluated.

Results
Cystatin C levels were significantly lower in patients with relapsing NMOSD than in those in remission (P < 0.001) or HCs (P < 0.05). CysC levels in NMOSD remission were higher than in HCs (P = 0.002). CysC levels were positively associated with age and negatively associated with brain lesion numbers in relapsing NMOSD (r = −0.252, P = 0.069).

Conclusion
Our results indicate a reduced serum level of CysC in patients with relapsing NMOSD and an increased level in remission. Further studies on the role of CysC in NMOSD are warranted.

Item Type: Journal Article
Publisher: Wiley
Copyright: © 2018 EAN
URI: http://researchrepository.murdoch.edu.au/id/eprint/41461
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