Active suppression rather than ignorance: Tolerance to abacavir-induced HLA-B*57:01 peptide repertoire alteration

Phillips, E.J. and Mallal, S.A. (2018) Active suppression rather than ignorance: Tolerance to abacavir-induced HLA-B*57:01 peptide repertoire alteration. Journal of Clinical Investigation, 128 (7). pp. 2746-2749.

Abstract

The discovery of HLA-B*57:01–associated abacavir hypersensitivity is a translational success story that eliminated adverse reactions to abacavir through pretreatment screening and defined a mechanistic model of an altered peptide repertoire. In this issue of the JCI, Cardone et al. have developed an HLA-B*57:01–transgenic mouse model and demonstrated that CD4+ T cells play a key role in mediating tolerance to the dramatically altered endogenous peptide repertoire induced by abacavir and postulate a known mechanism by which CD4+ T cells suppress DC maturation. This report potentially explains why 45% of HLA-B*57:01 carriers tolerate abacavir and provides a framework for future studies of HLA-restricted, T cell–mediated drug tolerance and hypersensitivity.

Item Type:	Journal Article
Murdoch Affiliation(s):	Institute for Immunology and Infectious Diseases
Publisher:	American Society for Clinical Investigation
Copyright:	© 2018 American Society for Clinical Investigation
URI:	http://researchrepository.murdoch.edu.au/id/eprint/41458

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