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Effect of exercise on acute postprandial glucose concentrations and interleukin-6 responses in sedentary and overweight males

Raman, A., Peiffer, J.J.ORCID: 0000-0002-3331-1177, Hoyne, G.F., Lawler, N.G., Currie, A.J. and Fairchild, T.J.ORCID: 0000-0002-3975-2213 (2018) Effect of exercise on acute postprandial glucose concentrations and interleukin-6 responses in sedentary and overweight males. Applied Physiology, Nutrition, and Metabolism . In Press.

Link to Published Version: https://doi.org/10.1139/apnm-2018-0160
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Abstract

This study examined the effect of two forms of exercise on glucose tolerance and concurrent changes in markers associated with the interleukin-6 (IL-6) pathways. Fifteen sedentary, overweight males (29.0±3.1 kg/m2) completed two separate, 3-day trials in randomised and counterbalanced order. An oral glucose tolerance test (OGTT; 75g) was performed at the same time on each successive day of the trial. Day two of each trial, consisted of a single 30-min workload-matched bout of either high-intensity interval exercise (HIIE; alternating 100% and 50% of V̇O2peak) or continuous moderate intensity exercise (CME; 60% V̇O2peak) completed 1h prior to the OGTT. Venous blood samples were collected pre-, immediately post-, 1h post- and 25h post-exercise for measurement of insulin, C-peptide, IL-6 and the soluble IL-6 receptors (sIL-6R; sgp130). Glucose area under the curve (AUC) were calculated from capillary blood samples collected throughout the OGTT. Exercise resulted in a modest (4.4%; p = 0.003) decrease in the glucose AUC when compared to the pre-exercise AUC; however, no differences were observed between exercise conditions (p = 0.65). IL-6 was elevated immediately and 1h post-exercise, whilst sgp130 and sIL-6R concentrations were reduced immediately post-exercise. In summary, exercise was effective in reducing glucose AUC which was attributed to improvements between 60 and 120 min of the OGTT, was in parallel with an increased ratio of IL-6 to sIL-6R, which accords with an increased activation via the ‘classical’ IL-6 signalling pathway. Our findings suggest acute HIIE did not improve glycaemic response when compared to CME. Trial Registration: ACTRN12613001086752

Item Type: Journal Article
Murdoch Affiliation: School of Health Professions
Publisher: National Research Council Canada
Copyright: © 2018 Canadian Science Publishing
URI: http://researchrepository.murdoch.edu.au/id/eprint/41453
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