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Aripiprazole and pregnancy: A retrospective, multicentre study

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Galbally, M.ORCID: 0000-0003-3909-1918, Frayne, J., Watson, S.J.ORCID: 0000-0001-7228-3490 and Snellen, M. (2018) Aripiprazole and pregnancy: A retrospective, multicentre study. Journal of Affective Disorders, 238 . pp. 593-596.

Link to Published Version: https://doi.org/10.1016/j.jad.2018.06.004
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Abstract

Background
Aripiprazole is a second generation antipsychotic medication that has been a useful addition to the treatment of severe mental illness due to its low metabolic and sedation risk profile. Pregnancy is a time of high risk of metabolic complications such as gestational diabetes and the postpartum period is often a time when sedation can compromise infant care. To date there is limited data in pregnancy on the safety of aripiprazole use. While available data do not suggest an elevated malformation risk in pregnancy, there is less information available on pregnancy and neonatal complications.

Methods
This study presents preliminary data on pregnancy and neonatal complications on 26 women who took aripiprazole in pregnancy. These women attended at antenatal clinics for women with severe mental illness at two hospitals in Australia.

Results
Overall aripiprazole was not associated with an increased risk of gestational diabetes. However, use of aripiprazole in pregnancy was associated with an increased risk of pregnancy hypertension, lower birth weight, shorter gestation at birth and higher rates of admission of the neonate than the expected population rates.

Limitations
These findings need to be replicated in a larger, well-designed study to ensure they do not reflect confounding factors.

Conclusions
Findings demonstrate that aripiprazole is unlikely to pose a metabolic risk in pregnancy but other pregnancy complications including hypertension, need to be examined in further studies.

Item Type: Journal Article
Murdoch Affiliation(s): School of Psychology and Exercise Science
Publisher: Elsevier
Copyright: © 2018 Published by Elsevier B.V.
URI: http://researchrepository.murdoch.edu.au/id/eprint/41220
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