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Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

Smart, L.ORCID: 0000-0003-4776-2849, Bosio, E., Macdonald, S.P.J., Dull, R., Fatovich, D.M., Neil, C. and Arendts, G. (2018) Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan. Journal of Critical Care, 47 . pp. 93-98.

Link to Published Version: https://doi.org/10.1016/j.jcrc.2018.06.015
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Abstract

Purpose
Endocan, a component of the endothelial glycocalyx (EG), has been linked with respiratory failure in sepsis. This study explored the temporal patterns of three EG biomarkers, including endocan, and their relationships with inflammation and respiratory failure.

Materials and methods
Plasma endocan, syndecan-1, and hyaluronan concentrations were measured in Emergency Department (ED) patients with sepsis due to pneumonia (n = 44) on ED arrival (T0), 1 h (T1), 3 h (T3) and 12–24 h (T24) later, with change over time tested using mixed regression models. Biomarker associations with inflammatory cytokine concentrations and with respiratory failure on days 1, 2 or 3, need for mechanical ventilation and 30-day mortality were also tested.

Results
Endocan concentration significantly decreased over time (T0–T24, P = 0.003) whereas both syndecan-1 (T0–T3, P = 0.010; T0–T24, P < 0.001) and hyaluronan (T0–T1, P = 0.010; T0–T3, P < 0.001; T0–T24, P = 0.003) significantly increased over time. Increased syndecan-1 was significantly correlated with neutrophil activation biomarkers and significantly increased the odds of respiratory failure (OR 1.18, 95% CI 1.05–1.33, P = 0.004), need for mechanical ventilation (OR 1.24, 95% CI 1.04–1.48, P = 0.014) and 30-day mortality (OR 1.29, 95% CI 1.07–1.55, P = 0.008).

Conclusion
Syndecan-1, but not endocan, was associated with neutrophil activation and was the best EG biomarker predictor of adverse clinical outcomes.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: Elsevier B.V.
Copyright: © 2018 Published by Elsevier Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/41214
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