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Metastatic Squamous Cell Carcinoma in a Northern Brown Bandicoot (Isoodon macrourus)

Beck, A.P., Shima, A.L., Bennett, M.D. and Johnson, L.K. (2017) Metastatic Squamous Cell Carcinoma in a Northern Brown Bandicoot (Isoodon macrourus). Veterinary Sciences, 4 (1). Article 10.

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Aside from a handful of notable exceptions, neoplasia is not reported as a major cause of mortality in wild animal populations and often goes undetected. For northern brown bandicoots specifically, there are few reported tumors in the literature and on file in the Australian Registry of Wildlife Health. This report describes a case of squamous cell carcinoma in a northern brown bandicoot (Isoodon macrourus), with metastases to the draining lymph nodes and lung. This neoplasm consisted predominantly of well-differentiated squamous cells and multifocal keratin pearls, with areas possibly consistent with epithelial to mesenchymal transition, as identified by positive immunohistochemical staining by both pancytokeratin (AE1/AE3) and vimentin. Additional investigations were negative for bandicoot papillomatosis carcinomatosis viruses.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: MDPI Multidisciplinary Digital Publishing Institute
Copyright: © 2017 by the authors
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