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Ectrodactyly in A Chinese Patient Born to A Mother with Neuromyelitis Optica Spectrum Disorder

Chang, Y.Y., Shu, Y.Q., Sun, X.B., Xu, C.F., He, D., Fang, L., Chen, C., Hu, X.Q., Kermode, A. and Wei, Q. (2018) Ectrodactyly in A Chinese Patient Born to A Mother with Neuromyelitis Optica Spectrum Disorder. Multiple Sclerosis Journal, 24 (3). pp. 418-419.

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Background: NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage.

Objective: To report a case of fetal malformation related to NMOSD.

Methods: We studied the case history a 30-year-old woman who was diagnosed with NMOSD who gave birth to an infant with ectrodactyly and the pathological manifestation of her placenta.

Results: The patient experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration.

Conclusion: It is important to be aware of NMOSD-related fetal malformation. Whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.

Item Type: Journal Article
Murdoch Affiliation(s): Institute for Immunology and Infectious Diseases
Publisher: Sage Publications
Copyright: © 2018 by SAGE Publications
Other Information: Poster presentation PACTRIMs 2017
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