Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua

Weiskopf, D., Grifoni, A., Arlehamn, C.S.L., Angelo, M., Leary, S., Sidney, J., Frazier, A., Mack, S.J., Phillips, E., Mallal, S., Cerpas, C., Balmaseda, A., Harris, E. and Sette, A. (2018) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua. Human Immunology, 79 (1). pp. 1-2.

Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on anonymized samples provided by 339 healthy adult blood bank donors in Managua, Nicaragua. The purpose of the study was to characterize allele frequencies in the local population to support studies of T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were detected for all class II loci (HLA-DPB1, -DQA1, -DQB1 and -DRB1), and at the class I C locus, but not at the class I A and B loci. The genotype data will be available in the Allele Frequencies Net Database.

Item Type:	Journal Article
Murdoch Affiliation(s):	Institute for Immunology and Infectious Diseases
Publisher:	Elsevier BV
Copyright:	© 2017 American Society for Histocompatibility and Immunogenetics
URI:	http://researchrepository.murdoch.edu.au/id/eprint/40252

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