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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka

Grifoni, A., Weiskopf, D., Lindestam Arlehamn, C.S., Angelo, M., Leary, S., Sidney, J., Frazier, A., Phillips, E., Mallal, S., Mack, S.J., Tippalagama, R., Goonewardana, S., Premawansa, S., Premawansa, G., Wijewickrama, A., De Silva, A.D. and Sette, A. (2017) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka. Human Immunology, 79 (2). pp. 87-88.

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DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in >30% of individuals, including the class II alleles DPB1 * 04:01, DPB1 * 02:01, DQB1 * 06:01 and DRB1 * 07:01, and the class I alleles A * 33:03 and A * 24:02. Genotype data will be available in the Allele Frequencies Net Database.

Item Type: Journal Article
Murdoch Affiliation(s): Institute for Immunology and Infectious Diseases
Publisher: Elsevier BV
Copyright: © 2018 American Society for Histocompatibility and Immunogenetics.
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