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TCR cross-reactivity and allorecognition: New insights into the immunogenetics of allorecognition

D’Orsogna, L.J., Roelen, D.L., Doxiadis, I.I.N. and Claas, F.H.J. (2012) TCR cross-reactivity and allorecognition: New insights into the immunogenetics of allorecognition. Immunogenetics, 64 (2). pp. 77-85.

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Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. It was previously unclear how T cells educated in the recipient thymus could recognize allogeneic HLA molecules. Recently it was shown that both naïve and memory CD4+ and CD8+ T cells are frequently cross-reactive against allogeneic HLA molecules and that this allorecognition exhibits exquisite peptide and HLA specificity and is dependent on both public and private specificities of the T cell receptor. In this review we highlight new insights gained into the immunogenetics of allorecognition, with particular emphasis on how viral infection and vaccination may specifically activate allo-HLA reactive T cells. We also briefly discuss the potential for virus-specific T cell infusions to produce GvHD. The progress made in understanding the molecular basis of allograft rejection will hopefully be translated into improved allograft function and/or survival, and eventually tolerance induction.

Item Type: Journal Article
Publisher: Springer-Verlag
Copyright: © 2011 The Author(s)
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